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Ferritin: What your test result actually shows, and why both low and high can matter
Ferritin is the marker that tells you what's actually in your iron stores, not just what's circulating in your blood right now. It's also one of the most misunderstood results on a blood test, since both a low reading and a high one can be telling you something important, and they don't mean the same thing.
Nicola Shubrook
6 min read


Iron and your thyroid: The connection nobody mentions
If your thyroid results keep coming back normal but you still have every symptom of an underactive thyroid, fatigue, low mood, weight changes, cold hands, low iron could be part of why. Your thyroid needs iron to actually make and use its hormones, and this link rarely gets mentioned.
Nicola Shubrook
2 min read


Iron and energy: why you're exhausted even when your GP says you're not anaemic
Being told your bloods are "normal" doesn't always mean your iron is where it needs to be for you to actually feel energised. There's a real gap between not being anaemic and having enough iron on board, and that gap is where a lot of unexplained fatigue lives.
Nicola Shubrook
2 min read


Six reasons your mood isn't improving despite doing everything right
You're eating well, moving your body, maybe even already in therapy, and your mood still isn't shifting the way you would expect. Here are six places worth looking that are easy to miss, because no single one of them tells the whole story on its own.
Nicola Shubrook
4 min read


Prescribed antidepressants for perimenopause low mood? Here’s what I think you should know first
If you have been offered antidepressants for low mood in perimenopause, without anyone assessing your hormones, your nutrient status, or your sleep, there are some things worth knowing before you decide.
Nicola Shubrook
5 min read


Blood sugar and mood: the connection no one explains to you
Mood swings, crashes, and cravings are often blamed on stress or hormones, but blood sugar is frequently the missing piece. There are more ways this gets disrupted day to day than most women realise, and this is how it all connects, and what actually helps.
Nicola Shubrook
6 min read


Why do I feel so flat in perimenopause, and what can I do about it?
Feeling emotionally flat in perimenopause is common, and it is not the same as clinical depression. Several interconnected body systems are involved, and understanding them is the first step to doing something about it.
Nicola Shubrook
4 min read


What is the gut-brain axis, and why does it matter for your mood in midlife?
Your gut and your brain are in constant communication. Not metaphorically, but through direct physical pathways that affect how you feel, how clearly you think, and how resilient your mood is. In midlife, when hormones are shifting and stress is often at a peak, this connection becomes even more important. Here's what the gut-brain axis is, and what it means for your mental health.
Nicola Shubrook
4 min read


"I want to come off my antidepressants": What you need to have in place first
Perhaps you have been on antidepressants for a while and are considering coming off of them, or maybe you’ve tried titrating down only to experience significant side effects. This is one of the most common conversations I have with midlife women, and something I tell every single one of them, is that you need to have good foundations in place before you even start reducing your medication. Let’s explore this further.
Nicola Shubrook
6 min read


Why folate matters for your mental health in midlife, and why folic acid is not the same thing
Folate (vitamin B9) plays a significant role in mood, brain function, and mental wellbeing throughout life. Midlife women are one of the groups most likely to be low in it. In this post we look at why folate matters for your mental health, why many women aren't getting enough, and why the synthetic version you'll find in most supplements is not a reliable substitute.
Nicola Shubrook
6 min read


Is There a Link Between Bile Acids, the Microbiome, and Mental Health?
We often think of bile as simply a digestive fluid, something that helps break down fats after a meal. But emerging research is revealing a much broader role. Bile acids are not just digestive helpers; they are powerful signalling molecules that interact with the gut microbiome, influence inflammation, and may even shape brain function.
Sophie Nielsen
3 min read


How Bile Flow Influences Your Gut Microbiome and Health
When we think about digestion, bile often flies under the radar. But this little digestive fluid plays a massive role in breaking down fats, removing toxins, and even shaping the health of your gut microbiome, espically in perimenopause. Let’s dive into bile acid formation, its flow, and why it matters for your gut.
Sophie Nielsen
3 min read


Progesterone: The forgotten hormone in midlife mood
Oestrogen gets SO much attention when it comes to women’s health, especially in perimenopause and menopause. Of course it is a really important hormone, but it gets far more airtime than its sister hormone, progesterone.
Progesterone is one of the most important – and most overlooked – hormones when it comes to midlife mood, anxiety and sleep.
Nicola Shubrook
4 min read


Looking Beneath the Surface: A Functional-Medicine Approach to Perimenopause and Disordered Eating
When eating struggles resurface in midlife, the conversation is often reduced to weight, willpower or “just cutting back a bit”. For many women in perimenopause or postmenopause, this can feel deeply invalidating and can miss what is really going on beneath the surface - which is where a functional medicine, eating-disorder-informed approach steps in
Irina Pollastri
3 min read


Gut Health and Restrictive Eating in Perimenopause: When “Healing” Becomes Another Set of Rules
Gut health plays a key role in perimenopause. As oestrogen declines, the gut microbiome changes—often reducing bacterial diversity and affecting hormone metabolism. This can lead to bloating, constipation, loose stools, and food sensitivities, compounding common midlife symptoms. Understanding this connection helps women support their gut, balance hormones, and ease the physical and emotional challenges of menopause transition.
Irina Pollastri
3 min read


The Gut-Brain Depression Axis: How Dysbiosis Inflames Your Brain
The Gut-Brain Depression Axis: How Dysbiosis Inflames Your Brain. About 90% of your body's serotonin is produced in your gut—but that serotonin doesn't travel to your brain. It stays in your gut and peripheral tissues, regulating digestion, immune function, and signalling. Your brain makes its own serotonin from tryptophan (an amino acid from protein).
Nicola Shubrook
4 min read


Thyroid Dysfunction and Depression: Why "Normal" Labs Might Be Missing Your Real Problem
If you've had blood work done showing your thyroid is "fine," but you're still struggling with depression, you're not alone.
Nicola Shubrook
6 min read


How You Can Rewire Your Brain Away From Chronic Stress
How You Can Rewire Your Brain Away From Chronic Stress - we have broken down some actions you can take to begin to reset the balance.
Nicola Shubrook
3 min read


Methylation, Detoxification & Depression: The Hidden Biochemical Block
Deep inside every cell in your body, a process called methylation is happening right now. But when methylation becomes dysregulated you accumulate stress chemicals in your bloodstream, your neurotransmitters don't get cleared properly, your oestrogen backs up, and you feel anxious, depressed, and wired but exhausted.
Nicola Shubrook
5 min read


Cortisol Dysregulation and Depression: How Chronic Stress Rewires Your Brain
Cortisol is supposed to be your ally. But when cortisol is elevated chronically, day after day, month after month, it stops being protective and becomes destructive. Chronically high cortisol doesn't just make you feel stressed - it literally rewires your brain toward depression.
Nicola Shubrook
4 min read
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